Tetrahedron letters

Microwave-assisted deuterium exchange reactions for the preparation of reactive intermediates

K Fodor-Csorba, G Galli, S Holly, E Gács-Baitz

文献索引：Fodor-Csorba, Katalin; Galli, Giancarlo; Holly, Sandor; Gacs-Baitz, Eszter Tetrahedron Letters, 2002 , vol. 43, # 21 p. 3789 - 3792

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被引用次数: 33

摘要

Deuterium labelling of a number of ketones was achieved on a preparative scale by a microwave-assisted deuterium exchange reaction with D2O/CF3COOD. The reaction was rapid (< 15 min) and highly isotope-efficient (ca. 100%), even though deuterium incorporation can be decreased during work-up (85–90%). No exchange reaction was observed for aryl protons of aromatic ketones.