Synthesis and biological activity of peptide antagonists of luliberin (luteinizing hormone-releasing hormone)

GW Moersch, MC Rebstock, EL Wittle…

文献索引：Moersch,G.W. et al. Journal of Medicinal Chemistry, 1979 , vol. 22, p. 935 - 943

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被引用次数: 17

摘要

A series of des-His2 octa-and nonapeptide analogues of luliberin (luteinizing hormone- releasing hormone) with modifications in the 1 and 6 positions, and in some instances the 10 position, has been prepared. Some of these analogues are potent inhibitors of luliberin in vitro and in vivo. The use of ultraviolet absorption measurements for evaluating peptides containing tyrosine and tryptophan is described. An efficient synthesis of 0-methyl-D- ...