A new approach to remote asymmetric induction in the diastereoselective reduction of γ-keto esters by use of a chiral podand as chiral auxiliary

Y Tamai, S Koike, A Ogura, S Miyano

文献索引：Tamai, Yasufumi; Koike, Shinji; Ogura, Atsuhiko; Miyano, Sotaro Journal of the Chemical Society, Chemical Communications, 1991 , # 12 p. 799 - 800

全文：HTML全文

被引用次数: 11

摘要

Diastereoselective reduction of chirally modified keto acids is a practical method for the synthesis of optically active hydroxy acid derivatives, which are important intermediates in the synthesis of optically active natural products. While several chiral auxiliaries have been reported for the efficient dia- stereoselective reduction of a- and (3-keto acids,l those for y-keto acids have not yet been found2 presumably because of the difficulty in carrying out the remote ...