Preliminary pharmacology of benzocycloheptane derivatives related to amphetamine

RM Parkhurst, PA Sturm, H Johnson…

文献索引：Parkhurst,R.M. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 1394 - 1396

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摘要

(Table I, 2-4). An intimate mixture of'the appropriate piperazine 12-1 I (1 equiv) and 6- methoxy-8-aminoquinoline (6 equiv) was heated under nitrogen at 120-125" for 19 hr. The melt was cooled at room temperature. rendered hasic with 1 3'NaOH. and extracted with CHCIs. After drying (MgS04). the CHCIs was removed in uacuo and the oily residue dissolved in ethanol and treated with excess alcoholic oxalic acid. The insoluble ...