Catalytic asymmetric hydroxymethylation of silicon enolates using an aqueous solution of formaldehyde with a chiral scandium complex

…, T Hamada, K Manabe, S Kobayashi

文献索引：Ishikawa, Shunpei; Hamada, Tomoaki; Manabe, Kei; Kobayashi, Shu Journal of the American Chemical Society, 2004 , vol. 126, # 39 p. 12236 - 12237

全文：HTML全文

被引用次数: 120

摘要

Catalytic asymmetric hydroxymethylation of silicon enolates has been achieved. In this reaction, an aqueous solution of formaldehyde can be used to realize an easy and safe procedure, and high enantioselectivities have been obtained. This is the first example of catalytic asymmetric reactions in aqueous media with a chiral scandium complex.