Tetrahedron letters

Short synthesis of protease inhibitors via modified Passerini condensation of N-Boc-α-aminoaldehydes

L Banfi, G Guanti, R Riva, A Basso, E Calcagno

文献索引：Banfi, Luca; Guanti, Giuseppe; Riva, Renata; Basso, Andrea; Calcagno, Emiliano Tetrahedron Letters, 2002 , vol. 43, # 22 p. 4067 - 4069

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被引用次数: 66

摘要

Extension of the previously reported modification of Passerini multicomponent reaction (involving condensation with N-Boc-α-aminoaldehydes followed by a deprotection– transacylation step) to α-aminoacid derived carboxylic or isocyanide components, allowed the highly convergent and short synthesis of complex peptidomimetic structures, including known potent inhibitors of serine proteases.