Synthesis of N, N'-Orthogonally Protected (S)-Piperazine-2-carboxylic Acid

AM Warshawsky, MV Patel…

文献索引：Warshawsky, Alan M.; Patel, Meena V.; Chen, Teng-Man Journal of Organic Chemistry, 1997 , vol. 62, # 18 p. 6439 - 6440

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被引用次数: 16

摘要

Piperazine-2-carboxylic acid (1) is a conformationally restricted nonproteinogenic amino acid which has been incorporated into a number of medicinally useful compounds. N-methyl- D-aspartate (NMDA) antagonist 21 and HIV protease inhibitor 32 provide examples. Piperazine-2-carboxylic acid is commercially available only in racemic form. Homochiral material has been obtained from racemic preparations by separating enantiomers through ...