Tetrahedron letters

A new synthesis of (−)-anisomycin or (+)-anisomycin starting from D-tyrosine or L-tyrosine

S Jegham, BC Das

文献索引：Jegham; Das Tetrahedron Letters, 1988 , vol. 29, # 35 p. 4419 - 4422

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被引用次数: 24

摘要

Qxtension with the anion derived from his (2, 2, 2-trifluoroethyl)(methoxycarhonylmethyl)- phosphonate at-78 C afforded exclusively lo (Z)-a, B-unsaturated ester (6). In order to avoid or binimize any possible racemization of the chiral centre, the aldehyde (5) was used immediate-'ly, without purification, for the olefination step. Our strategy required that the olefination product (5) have the desired (Z) geometry of the double dond for the ...