Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-α-2, 3-Gal-β-O-PNP

…, SL Scheuerl, JH Naismith, S Schenkman…

文献索引：Harrison, Jennifer A.; Kartha; Turnbull; Scheuerl, Shona L.; Naismith, James H.; Schenkman, Sergio; Field, Robert A. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 2 p. 141 - 144

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被引用次数: 25

摘要

NeuAc-α-2, 3-Gal-β-O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. The turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. In addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-α-2, 3-Gal-β-O-PNP were apparent.