Tetrahedron letters

Regioselective synthesis of N-substituted-4-substituted isothiazolidine-1, 1-dioxides

E Cleator, FJ Sheen, MM Bio, KMJ Brands, AJ Davies…

文献索引：Cleator, Ed; Sheen, Faye J.; Bio, Matthew M.; Jos Brands; Davies, Antony J.; Dolling, Ulf-H. Tetrahedron Letters, 2006 , vol. 47, # 25 p. 4245 - 4248

全文：HTML全文

被引用次数: 7

摘要

A novel and efficient synthesis of a range of racemic and enantioenriched N-substituted-4- substituted isothiazolidine-1, 1-dioxides from epoxides and sulfonamides is described. The critical choice of the activating group for the cyclization event is discussed. The application of this methodology to the synthesis of N-substituted-4, 5-disubstituted derivatives is also described.