Flavin-6-carboxylic acids as novel and simple flavoenzyme models. Nonenzymatic stabilization of the flavin semiquinone radical and the 4a-hydroperoxyflavin by …

T Akiyama, F Simeno, M Murakami…

文献索引：Akiyama; Simeno; Murakami; Yoneda Journal of the American Chemical Society, 1992 , vol. 114, # 17 p. 6613 - 6620

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被引用次数: 40

摘要

Abstract: Novel flavin derivatives, 1O-ethyl-3-methylisoalloxazine-6-carboxylic acid (1) and 10-ethyl-3-methylisoall-oxazine-6, 8-dicarboxylic acid (2), which have a carboxyl group at C (6) position, were prepared. Even in the absence of metal cations and under aerobic condition, these flavin derivatives produced the corresponding stable semiquinone radicals by the dithionite reduction in sodium phosphate buffer (pH 6.89). Hyperfine electron spin ...