Purine Nucleoside Analogues; 9: Benzylation of N2-Acetyl-8-bromoguanine

M Madre, N Panchenko, R Zhuk, JA Geenevasen…

文献索引：Madre, Marina; Panchenko, Natella; Zhuk, Regina; Geenevasen, Jan A.; Van Den Burg, Alida; Koomen, Gerrit-Jan Synthesis, 1999 , # 5 p. 775 - 778

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被引用次数: 7

摘要

Abstract: A one-step synthesis of regioisomeric N-and O-benzylated 8-bromoguanines 4, 5, 9, 10 via N2-acetyl-8-bromoguanine (2) is described. The possibility to prepare 8-oxo-and 8- chloroguanine derivatives 3, 11, 12 from the same compound 2 is demonstrated. 1H and 13C NMR spectra are used to locate the sites of aralkylation. Key words: N2-acetyl-8- bromoguanine, benzylation, regioisomers