Stereoselective synthesis of N, O, O, O-tetraacetyl-D-ribo-phytosphingosine, N, O, O-triacetyl-D-erythro-sphingosine and N, O, O-triacetyl sphingonine from a …
R Mettu, NR Thatikonda, OS Olusegun, R Vishvakarma…
Abstract An efficient protocol for the stereoselective synthesis of tetraacetyl-D-ribo- phytosphingosine, triacetyl-D-erythro-sphingosine and triacetyl sphinganine has been devised from a common chiral intermediate derived from commercially available D-mannitol. The key steps involved are Sharpless epoxidation, Miyashita C (2) selective endo mode azide opening of 2, 3-epoxy alcohol, and selective E-Wittig olefination. Keywords: ...
