N-Aryl 3-halogenated azetidin-2-ones and benzocarbacephems, inhibitors of. beta.-lactamases

…, H Molines, R Labia, M Wakselman

文献索引：Joyeau, Roger; Molines, Huguette; Labia, Roger; Wakselman, Michel Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 370 - 374

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被引用次数: 41

摘要

Chemistry Cyclization of P-halopropionamides is an efficient method for the synthesis of P- la~ tams.'~~ Use of NaH as a base in a diluted CHZClz-DMF solution reduces the amount of the acrylamide side product formed by a competitive b-elimination reaction. 8 This procedure has been now applied for the preparation of N-aryl-3-halo-and-3, 3- dihaloazetidin-2-ones 3. Most of the starting sustituted propionyl halides 5 are easily ...