Concise asymmetric total synthesis of scyphostatin, a potent inhibitor of neutral sphingomyelinase

…, T Okitsu, N Murata, O Kubo, R Li, Y Kita

文献索引：Fujioka, Hiromichi; Okitsu, Takashi; Sawama, Yoshinari; Murata, Nobutaka; Li, Ruichuan; Kita, Yasuyuki Journal of the American Chemical Society, 2006 , vol. 128, # 17 p. 5930 - 5938

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被引用次数: 30

摘要

Abstract The concise asymmetric total synthesis of scyphostatin has been achieved by condensation of the optically active cyclohexane unit, prepared from the commercially available 1, 4-cyclohexadiene by our own method, and the side chain, prepared by the method developed by Hoye and Tennakoon (TR Hoye, MA Tennakoon, Org. Lett. 2000, 2, 1481–1483). The modification of the epoxy cyclohexenone unit was achieved in a late ...