Organic letters

Design and development of cyclohexane-based P, N-ligands for transition metal catalysis

A Caiazzo, S Dalili, AK Yudin

文献索引：Caiazzo, Aldo; Dalili, Shadi; Yudin, Andrei K. Organic Letters, 2002 , vol. 4, # 15 p. 2597 - 2600

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被引用次数: 55

摘要

A new class of cyclohexane-based P, N-ligands is readily obtained through aziridine ring opening with suitable phosphorus nucleophiles under acidic conditions. trans-1-Amino-2- diphenylphosphinocyclohexane is resolved with tartaric acid to give the final product in> 99% ee. The new ligands show high stability toward oxidation at the phosphorus atom.