Advanced Synthesis & Catalysis

Asymmetric Bio??amination of Ketones in Organic Solvents

FG Mutti, W Kroutil

文献索引：Mutti, Francesco G.; Kroutil, Wolfgang Advanced Synthesis and Catalysis, 2012 , vol. 354, # 18 p. 3409 - 3413

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被引用次数: 43

摘要

Abstract ω-Transaminases, employed as a lyophilised crude cell-free extract, were successfully employed in organic solvent for the asymmetric amination of ketones without the need for immobilisation. Best activity was found for methyl tert-butyl ether (MTBE) at a water activity of 0.6. The ω-transaminases (9 different enzymes) accepted efficiently 2- propylamine as amine donor when used in the solvent, which is not the case when they ...