Benzyloxyarylaliphatic acids: Synthesis and quantitative relations between structure and antiinflammatory activity

M Kuchař, V Rejholec, B Brunová…

文献索引：Kuchar; Rejholec; Brunova; et al. Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 9 p. 2514 - 2524

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被引用次数: 1

摘要

Abstract The paper describes synthesis of substituted benzyloxyarylaliphatic acids, IV, and their efficacy in stabilization the erythrocyte membrane against hypotonic haemolysis and their antiinflammatory effect in inhibition of the kaolin oedema. The quantitative relations between these efficacies and the physico-chemical and structural parameters of the acids have been analysed. The two activities depend on the overall lipophilicity and acidity of ...