Tetrahedron

A convergent synthesis of (S)-β-methyl-2-aryltryptamine based gonadotropin releasing hormone antagonists

…, RB Toupence, F Ujjainwalla, JR Young, MT Goulet

文献索引：Walsh, Thomas F; Toupence, Richard B; Ujjainwalla, Feroze; Young, Jonathan R; Goulet, Mark T Tetrahedron, 2001 , vol. 57, # 24 p. 5233 - 5241

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被引用次数: 80

摘要

A practical synthesis of (S)-β-methyl-2-aryltryptamine based gonadotropin releasing hormone antagonists which features a palladium-catalyzed Larock indole synthesis and a palladium-catalyzed Suzuki–Miyaura sequence to install the 2-position aryl substituent is reported.