The syntheses of 2-oxo-l, 8-naphthyridine-3-carboxylic acid derivatives having potent gastric antisecretory properties in the pyloric-ligated (Shay) rat model are described. Two of the more potent compounds tested that were selected for more detailed dose-response evaluation were 4-amino-l-ethyl-l, 2-dihydro-2-oxonaphthyridine-3-carboxylic acid ethyl ester (35) and l-ethyl-1, 2-dihydro-7-methyl-4-(4-methyl-l-piperazinyl)-2-oxo-l, 8- ...
