2, 5-Disubstituted pyridines as potent GPR119 agonists

Y Wu, JD Kuntz, AJ Carpenter, J Fang, HR Sauls…

文献索引：Wu, Yulin; Kuntz, Judith D.; Carpenter, Andrew J.; Fang, Jing; Sauls, Howard R.; Gomez, Daniel J.; Ammala, Carina; Xu, Yun; Hart, Shane; Tadepalli, Sarva Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 8 p. 2577 - 2581

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被引用次数: 28

摘要

A series of 2-piperazinyl-5-alkoxypyridines were synthesized and screened against human GPR119 receptor. Through SAR analysis, compounds containing 2-alkylsulfonylpiperazinyl- 5-alkoxypyridines were discovered and found to be potent agonists of the human GPR119 receptor.