Synthesis and testing of 3-acetyl-2, 5-disubstituted-2, 3-dihydro-1, 3, 4-oxadiazole derivatives for antifungal activity against selected Candida Species

CS Oliveira, BF Lira, JM Barbosa-Filho…

文献索引：De Oliveira, Cledualdo S.; Lira, Bruno F.; Barbosa-Filho, Jose M.; Lorenzo, Jorge G. F.; De Menezes, Camilla P.; Dos Santos, Jessyca M. C. G.; De Lima, Edeltrudes O.; De Athayde-Filho, Petronio F. Journal of the Brazilian Chemical Society, 2013 , vol. 24, # 1 p. 115 - 120

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被引用次数: 1

摘要

ABSTRACT A series of 21 1, 3, 4-oxadiazoline derivatives was synthesized by cyclization of N-acylhydrazones with acetic anhydride and evaluated for their in vitro antifungal activity against six Candida strains: Candida albicans (ATCC 90028 and LM V-42), C. krusei (ATCC 6258 and LM 12 C) and C. tropicalis (ATCC 13803 and LM 14). The Candida strains were found to be sensitive to some of the compounds, which inhibited the growth by 50-90%, ...