An efficient and versatile method for the preparation of a series of perfluoroalkyl containing spiro cyclic barbituric acid derivatives is described. 7, 9-Dimethyl-2-(iodomethyl)-3- (perfluoroalkylmethyl) 7, 9-diazaspiro [4.5] decane-6, 8, 10-trione were prepared in good yields from 1, 3-dimethylbarbituric acid. The structures of these compounds were confirmed by 1H NMR, 13C NMR, IR, MS spectra and elemental analysis.
