Simplifying oligosaccharide synthesis: efficient synthesis of lactosamine and siaylated lactosamine oligosaccharide donors

…, E Eichler, WW Wakarchuk, M Gilbert…

文献索引：Mehta, Seema; Gilbert, Michel; Wakarchuk, Warren W.; Whitfield, Dennis M. Organic Letters, 2000 , vol. 2, # 6 p. 751 - 753

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被引用次数: 32

摘要

A practical sequence is described for converting d-glucosamine into peracetylated Gal (β-1, 4) GlcNTroc (β1-S) Ph and Neu5Ac (α-2, 3) Gal (β-1, 4) GlcNTroc (β1-S) Ph building blocks using a synthetic strategy based on chemoenzymatic oligosaccharide synthesis. The known trichloroethoxycarbonyl, N-Troc, protecting group was selected as a suitable protecting group for both enzymatic and chemical reaction conditions. These oligosaccharide ...