Synthesis of 2-Methylchromone-8-acetic Acids and 2-Methylchromone-8-carboxylic Acids

…, GLD Krupadanam, G Srimannarayana

文献索引：Jagadeesh; David Krupadanam; Srimannarayana Synthetic Communications, 2001 , vol. 31, # 10 p. 1547 - 1557

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被引用次数: 7

摘要

2-Hydroxy-3-allylacetophenones on Claisen condensation with EtOAc/Na gave intermediate diketone, followed by cyclization in AcOH/HCl gave 8-allyl/-1-propenylchromones, which on ozonolysis gave 8-acetaldehydes or 8-carboxaldehydes. The above aldehydes on oxidation with KMnO4 furnished corresponding 8-acetic acids and 8-carboxylic acids.