Continuous flow ligand-free Heck reactions using monolithic Pd [0] nanoparticles

N Nikbin, M Ladlow, SV Ley

文献索引：Nikbin, Nikzad; Ladlow, Mark; Ley, Steven V. Organic Process Research and Development, 2007 , vol. 11, # 3 p. 458 - 462

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被引用次数: 109

摘要

An automated reactor has been developed for performing ligand-free Heck reactions in continuous flow mode. The reactor utilises a monolithic reactor cartridge derivatised with Pd (0) nanoparticles in-line with a scavenging cartridge containing Quadrapure-TU to efficiently capture palladium residues and thereby afford Heck products directly in high purity.