Synthesis of new sulfonamides as lipoxygenase inhibitors

…, M Ashraf, I Afzal, SA Shahzad, M Shafiq

文献索引：Mustafa, Ghulam; Khan, Islam Ullah; Ashraf, Muhammad; Afzal, Iftikhar; Shahzad, Sohail Anjum; Shafiq, Muhammad Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 8 p. 2535 - 2539

全文：HTML全文

被引用次数: 24

摘要

The present study describes a convenient method for the synthesis of new lipoxygenase inhibitors, 4-(toluene-4-sulfonylamino)-benzoic acids from p-amino benzoic acid. Reaction of p-amino benzoic acid with p-toluenesulfonyl chloride provided thirteen N-and O-alkylation products 4a–4m in moderate to good yields. Lipoxygenase inhibition of newly formed sulfonamide derivatives was investigated and some of these compounds 4m, 4g, 4e, 4f ...