REVERSIBLE N, O-HALOACYL SHIFT IN SERINE DERIVATIVES WITH ANTITUMOR ACTIVITY

I Levi, JWR Weed, G Laflamme…

文献索引：Levi,I. et al. Canadian Journal of Chemistry, 1961 , vol. 39, p. 2491 - 2501

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被引用次数: 4

摘要

Large doses of N-dichloroacetyl-dl-serine sodium salt were required to cause regression of Sarcoma-37 in mice. About 56% of the unchanged compound was recovered from the urine. These observations suggest that the antitumor activity may reside in a metabolic product of the N-dichloroacetyl serine. It is postulated that the active compound is the corresponding O- dichloroacetyl-dl-serine formed from the N-acyl compound by an in vivo enzymatically ...