Selective biocatalytic aminolysis of (±)-epichlorohydrin: Synthesis and ICAM-1 inhibitory activity of (S)-(+)-3-arylamino-1-chloropropan-2-ols

…, S Bhatia, A Dhawan, S Balwani, S Sharma…

文献索引：Gupta, Pankaj; Bhatia, Sumati; Dhawan, Ashish; Balwani, Sakshi; Sharma, Shatrughan; Brahma, Raju; Singh, Rajpal; Ghosh, Balaram; Parmar, Virinder S.; Prasad, Ashok K. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 7 p. 2263 - 2268

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被引用次数: 9

摘要

Regio-and enantioselective synthesis of (S)-(+)-3-arylamino-1-chloropropan-2-ols has been achieved by the epoxide ring opening of (±)-epichlorohydrin with different aromatic amines in the presence of Candida rugosa lipase. Activities of seven model (S)-(+)-3-arylamino-1- chloropropan-2-ols, out of 10 compounds synthesized, have been evaluated for the inhibition of tumor necrosis factor-α TNF-α) induced expression of intercellular adhesion ...