Structure-function correlation of chloroquine and analogues as transgene expression enhancers in nonviral gene delivery

J Cheng, R Zeidan, S Mishra, A Liu…

文献索引：Cheng, Jianjun; Zeidan, Ryan; Mishra, Swaroop; Liu, Aijie; Pun, Suzie H.; Kulkarni, Rajan P.; Jensen, Gregory S.; Bellocq, Nathalie C.; Davis, Mark E. Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6522 - 6531

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被引用次数: 93

摘要

To understand how chloroquine (CQ) enhances transgene expression in polycation-based, nonviral gene delivery systems, a number of CQ analogues with variations in the aliphatic amino side chain or in the aromatic ring are synthesized and investigated. Our studies indicate that the aliphatic amino moiety of CQ is essential to provide increased gene expression. Further, the enhancements are more dramatically affected by changes to the ...