Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo
S Ghosh, JMW Chan, CR Lea, GA Meints…
文献索引：Ghosh, Subhash; Chan, Julian M. W.; Lea, Christopher R.; Meints, Gary A.; Lewis, Jared C.; Tovian, Zev S.; Flessner, Ryan M.; Loftus, Timothy C.; Bruchhaus, Iris; Kendrick, Howard; Croft, Simon L.; Kemp, Robert G.; Kobayashi, Seike; Nozaki, Tomoyoshi; Oldfield, Eric Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 175 - 187
The effects of a series of 102 bisphosphonates on the inhibition of growth of Entamoeba histolytica and Plasmodium falciparum in vitro have been determined, and selected compounds were further investigated for their in vivo activity. Forty-seven compounds tested were active (IC50< 200 μM) versus E. histolytica growth in vitro. The most active compounds (IC50~ 4-9 μM) were nitrogen-containing bisphosphonates with relatively large aromatic ...
