Discovery of indole-containing tetracycles as a new scaffold for androgen receptor ligands

X Zhang, X Li, GF Allan, A Musto, SG Lundeen…

文献索引：Zhang, Xuqing; Li, Xiaojie; Allan, George F.; Musto, Amy; Lundeen, Scott G.; Sui, Zhihua Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 12 p. 3233 - 3237

全文：HTML全文

被引用次数: 21

摘要

A novel series of tetracyclic indoles have been designed, synthesized and evaluated as androgen receptor (AR) ligands. Studies of structure–activity relationships (SARs) were investigated, which led to some compounds in this series as strong binders to androgen receptors.