Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3

…, JK Muckelbauer, AM Smallwood, H Chen…

文献索引：Yue, Eddy W.; DiMeo, Susan V.; Higley, C. Anne; Markwalder, Jay A.; Burton, Catherine R.; Benfield, Pamela A.; Grafstrom, Robert H.; Cox, Sarah; Muckelbauer, Jodi K.; Smallwood, Angela M.; Chen, Haiying; Chang, Chong-Hwan; Trainor, George L.; Seitz, Steven P. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 2 p. 343 - 346

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被引用次数: 21

摘要

New indeno [1, 2-c] pyrazol-4-one cyclin dependent kinase inhibitors have been disclosed. The most promising compounds are nanomolar enzyme inhibitors with excellent activity against tumor cells. The most advanced compound retains cell culture activity even in the presence of human serum proteins. The most advanced compound did not kill the normal fibroblast line AG1523.