Asymmetric Conjugate Silyl Transfer in Iterative Catalytic Sequences: Synthesis of the C7–C16 Fragment of (+)??Neopeltolide

E Hartmann, M Oestreich

文献索引：Hartmann, Eduard; Oestreich, Martin Angewandte Chemie - International Edition, 2010 , vol. 49, # 35 p. 6195 - 6198

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被引用次数: 43

摘要

The assembly of recurring structural motifs in complex molecules, such as 1, 3,… n- polymethylated or 1, 3,… n-polyhydroxylated carbon chains (n= odd integers), is elegantly realized by several unique iterative sequences.[1] These approaches enable the stereoselective synthesis of either Me, Me [2–5] or OH, OH [6](I and II; Figure 1) but not Me, OH (or OH, Me) arrangements (III; Figure 1). We thus sought a flexible strategy that would ...