Facile synthesis of novel 3??quinoxalinyl??1, 5??benzodiazepines via ring transformation. Stable tautomers in the 1, 5??benzodiazepin??2??one ring system

Y Kurasawa, Y Okamoto, K Ogura…

文献索引：Kurasawa; Okamoto; Ogura; Takada Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 3 p. 661 - 664

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被引用次数: 7

摘要

Abstract Novel 3-quinoxalinyl-1, 5-benzodiazepines 4, 5, 6, 9, 10 were synthesized via the ring transformation of 3-(N, N-dimethylcarbamoyl) furo [2, 3-b] quinoxaline hydrochloride (1). The 3-quinoxalinyl-1, 5-benzodiazepine hydrochlorides 4 and 6 are the tautomers of the N 1′-H (or N 5-H) form and the C 3-H form, respectively, which are stable in solid and solution. However, 4 (NH form) was found to be converted into 6 (C 3-H form) by refluxing ...