Steroids

D-ring substituted 1, 2, 3-triazolyl 20-keto pregnenanes as potential anticancer agents: Synthesis and biological evaluation

AH Banday, SA Shameem, BD Gupta, HMS Kumar

文献索引：Banday, Abid H.; Shameem, Shameem A.; Gupta; Kumar, H.M. Sampath Steroids, 2010 , vol. 75, # 12 p. 801 - 804

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被引用次数: 85

摘要

A facile synthesis of 21-triazolyl derivatives of pregnenolone and their potential antitumour activity is reported. The scheme involves the transformation of the starting pregnenolone acetate into pregnenolone, conversion of pregnenolone to 21-bromo pregnenolone and finally the one-pot, two-step in situ conversion of the bromo derivative to the 21-triazolyl pregnenolone using the 'click chemistry'approach. These derivatives were screened for ...