A fluorous and click approach for screening potential PET probes: evaluation of potential hypoxia biomarkers

…, L Carroll, K Bhakoo, J Declerck, V Gouverneur

文献索引：Bejot, Romain; Carroll, Laurence; Bhakoo, Kishore; Declerck, Jerome; Gouverneur, Veronique Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 1 p. 324 - 329

全文：HTML全文

被引用次数: 13

摘要

Radiopharmaceuticals for nuclear imaging are essentially targeting molecules, labeled with short-lived radionuclides (eg, F-18 for PET). A significant drawback of radiopharmaceuticals development is the difficulty to access radiolabeled molecule libraries for initial in vitro evaluation, as radiolabeling has to be optimized for each individual molecule. The present paper discloses a method for preparing libraries of 18F-labeled radiopharmaceuticals ...