Efficient chemoenzymatic dynamic kinetic resolution of 1-heteroaryl ethanols
…, Z Hamersak, MA Svensson, ABE Minidis
文献索引：Vallin, Karl S. A.; Posaric, David Wensbo; Hamersak, Zdenko; Svensson, Mats A.; Minidis, Alexander B. E. Journal of Organic Chemistry, 2009 , vol. 74, # 24 p. 9328 - 9336
The scope and limitation of the combined ruthenium-lipase induced dynamic kinetic resolution (DKR) through O-acetylation of racemic heteroaromatic secondary alcohols, ie, 1- heteroaryl substituted ethanols, was investigated. After initial screening of reaction conditions, Candida antarctica lipase B (Novozyme 435, N435) together with 4-chloro- phenylacetate as acetyl-donor for kinetic resolution (KR), in conjunction with the ...
