6-Azido d-galactose transfer to N-acetyl-d-glucosamine derivative using commercially available β-1, 4-galactosyltransferase

…, C Rihouey, S Couve-Bonnaire, M Bardor, P Lerouge…

文献索引：Bosco, Michael; Gall, Sophie Le; Rihouey, Christophe; Couve-Bonnaire, Samuel; Bardor, Muriel; Lerouge, Patrice; Pannecoucke, Xavier Tetrahedron Letters, 2008 , vol. 49, # 14 p. 2294 - 2297

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被引用次数: 9

摘要

A new strategy to tag glycoproteins carrying terminal GlcNAc was developed using commercially available bovine β-1, 4-galactosyltransferase (GalT) and UDP-6- azidogalactose. The azide function was then allowed to react via a biotinylated Staudinger– Bertozzi probe demonstrating the usefulness of such a procedure to tag any glycoprotein possessing a N-acetylglucosamine terminal residue from any type of cell lysate.