Journal of medicinal chemistry

Synthesis and characterization of N2-(pn-butylphenyl)-2'-deoxyguanosine and its 5'-triphosphate and their inhibition of HeLa DNA polymerase. alpha.

GE Wright, LW Dudycz

文献索引：Wright, George E.; Dudycz, Lech W. Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 175 - 181

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被引用次数: 89

摘要

Department of Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605. Received July 5, 1983~-@-n-Butylphenyl)-2'-deoxyguanosine (BuPdG) and its 5'-triphosphate (BuPdGTP), expected to be inhibitors of eukaryotic DNA polymerase CY, have been synthesized. BuPdG was synthesized by two methods and characterized by lH NMR and by chemical relation to guanosine. Direct synthesis ...