We have adopted a practical three-step route for the synthesis of 2'-and 3'-deoxy analogues of N6-substituted adenosines: protection of the hydroxyl groups, replacement of the NG- amino by a better leaving group, and combined deprotection and N6-amination in the last step. This route was used to synthesize deoxy analogues of CPA, CHA, and R-and S-PIA. The compounds were tested on the adenosine A1 and Aza receptors in our search for ...
