Synthesis of novel isothiazolopyridines and their in vitro evaluation against Mycobacterium and Propionibacterium acnes

W Malinka, P Świątek, M Śliwińska, B Szponar…

文献索引：Malinka, Wieslaw; Swiatek, Piotr; Sliwinska, Malgorzata; Szponar, Bogumila; Gamian, Andrzej; Karczmarzyk, Zbigniew; Fruzinski, Andrzej Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5282 - 5291

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被引用次数: 3

摘要

Abstract In this paper we describe synthesis, structures and some physicochemical properties of 20 isothiazolopyridines 8–13 substituted differently into an isothiazole ring as well as their in vitro antibacterial assays against Mycobacterium tuberculosis H37Rv, Mycobacterium fortuitum PCM 672 and Propionibacterium acnes PCM 2400. Compound 13a was found to be the most active derivative against M. tuberculosis H37Rv, ...