Design and synthesis of eugenol derivatives, as potent 15-lipoxygenase inhibitors

H Sadeghian, SM Seyedi, MR Saberi, Z Arghiani…

文献索引：Bakavoli; Nikpour; Rahimizadeh; Saberi; Sadeghian Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 5 p. 2120 - 2126

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被引用次数: 54

摘要

A group of 4-allyl-2-methoxyphenol (eugenol) esters were designed, synthesized, and evaluated as potential inhibitors of soybean 15-lipoxygenase (SLO). Compounds 4c, 4d 4f, 4p, and 4q showed the best IC50 in SLO inhibition (IC50= 1.7, 2.3, 2.1, 2.2, and 0.017 μM, respectively). All compounds were docked into SLO active site and showed that allyl group of compounds is oriented toward the iron atom in the active site of SLO. It is assumed that ...