Gossypol and derivatives: a new class of aldose reductase inhibitors

…, DL Vander Jagt, RE Royer

文献索引：Deck, Lorraine M.; Jagt, David L. Vander; Royer, Robert E. Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3301 - 3305

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被引用次数: 49

摘要

Gossypol and 17 derivatives were tested as inhibitors of aldose reductase from human placenta. Gossypol and a number of the derivatives were potent inhibitors. The order of inhibitory activity was interpreted in relation to the Kador-Sharpless pharmacophor model for the aldose reductase inhibitor site. The structural but not the electronic aspects of the model were found to apply to this series of compounds.