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The Journal of Organic Chemistry

Catalytic hydrogenation of pyrroles at atmospheric pressure

HP Kaiser, JM Muchowski

文献索引:Kaiser, Hans-Peter; Muchowski, Joseph M. Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4203 - 4209

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被引用次数: 36

摘要

N-(tert-Butoxycarbony1) pyrroles are catalytically hydrogenated to the corresponding pyrrolidines, over 5% platinum on carbon catalyst, at room temperature and atmospheric pressure. Under these conditions 0-benzyl groups are retained and 2, 5-disubstituted pyrroles are reduced predominantly or exclusively to the cis-2, 5-disubstituted pyrrolidines. This facile catalytic reduction of pyrroles was the central feature of convenient, high yield ...