Rhodanine??Based Tau Aggregation Inhibitors in Cell Models of Tauopathy

…, I Khlistunova, J Biernat, EM Mandelkow…

文献索引：Bulic, Bruno; Pickhardt, Marcus; Khlistunova, Inna; Biernat, Jacek; Mandelkow, Eva-Maria; Mandelkow, Eckhard; Waldmann, Herbert Angewandte Chemie - International Edition, 2007 , vol. 46, # 48 p. 9215 - 9219

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被引用次数: 109

摘要

The two histopathological hallmarks that characterize Alzheimer s disease (AD) are the extracellular amyloid plaques that are formed by β-amyloid fragments of the amyloid precursor protein (APP), and intracellular neurofibrillary tangles and neuropil threads, which consist of the microtubule-associated protein tau forming paired helical filaments with highly ordered structures, as recently corroborated by X-ray microcrystallography.[1] In addition, ...