Antibacterials. Synthesis and structure-activity studies of 3-aryl-2-oxooxazolidines. 1. The B group

…, MA Wuonola, RJ McRipley, DC Eustice…

文献索引：Gregory; Brittelli; Wang; Wuonola; McRipley; Eustice; Eberly; Bartholomew; Slee; Forbes Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1673 - 1681

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被引用次数: 220

摘要

1 by dialkyl carbonate heterocyclization to afford I (A= H, B= OH), whose arene ring was further elaborated by using electrophilic aromatic substitution methodology;(2) cycloaddition of substituted aryl isocyanates with epoxides to give A and B with a variety of values. I with B= OH or Br were converted to other" B" functionalities by using SN~ methodology. Antibacterial evaluation of compounds I with A= acetyl, isopropyl, methylthio, ...