(4) Our rationale for the design of bridged pyrimethamine analogs, of which 1 is only one example. was first presented in connection with the synthesis of fully aromatic l, 3- diaminobenso [flquinazolines;~ cf. EJ Modest, A. Rosowsky, S. Farber, and GE Foley, Abstracts of Papers, Ninth International Cancer Congress, Tokyo, Japan, October 24, 1966, p 325. The same concept has been invoked recently by Taylor and co-workers in their ...
