Enantioselektive α??Alkylierung von Asparagin??und Glutaminsäure über die Dilithium??enolatocarboxylate von 2??[3??Benzoyl??2??(tert??butyl)??1??methyl??5?? …
JD Aebi, D Seebach
文献索引：Aebi, Johannes D.; Seebach, Dieter Helvetica Chimica Acta, 1985 , vol. 68, p. 1507 - 1518
The pure methyl esters 10 of the heterocyclic carboxylic acids specified in the title were prepared in several steps by known methods from aspartic and glutamic acid, with overall yields of cn. 20%. The corresponding heterocyclic acids 11 were doubly deprotonated by LiNEt2/BuLi or LiN (i-Pr),/BuLi to give enolatocarboxylates (3). The latter were reacted with electrophiles (MeOD, MeI, C6H, CH2Br) to give the crystalline products 1&21 ...
