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Studies of the cyclic amidoacetal carbamate moiety of the maytansinoids

G Gormley Jr, YY Chan, J Fried

文献索引:Gormley, Glenn; Chan, Y. Y.; Fried, Josef Journal of Organic Chemistry, 1980 , vol. 45, # 8 p. 1447 - 1454

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被引用次数: 23

摘要

The intramolecular aldol reaction of 4e provided an unanticipated outcome leading not only to the desired six-membered urethanes 5 and 6 but giving rise also to the rearrangement product 7 via a subsequent intramolecular acyl migration. Thus, when the reaction was performed in a saturated solution of K2C03 in methanol for 5 min, all three products, 5, 6, and 7, could be isolated in approximately equal amounts by TLC or column ...